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The pharmacology and clinical toxicology of synthetic cannabinoids adb-fubinaca – case report
Adb-fubinaca is a synthetic cannabinoid and a potent cannabinoid receptor agonist. It is related to ab-pinaca, another synthetic cannabinoid found in cannabis. Adb-fubinaca has been studied extensively and its pharmacology and clinical toxicology are well understood. Several studies have been conducted to assess the toxicity of adb-fubinaca, and assays have been developed for the detection of this compound as well as other synthetic cannabinoids such as ab-chminaca, amb-fubinaca, adbica and adb-pinaca. The use of these synthetic cannabinoids can be purchased online from many vendors; however, it is important to note that the synthetic cannabinoids may not always be accurately labelled or identified correctly. Furthermore, reference standards should be used in order to identify the chemical structure of these compounds accurately. In a recent case report involving the use of the synthetic cannabinoid adb-fubinaca, a woman became violent and aggressive with her family before being taken in by emergency personnel a short time thereafter. Remarkable findings at autopsy included pulmonary vascular congestion and thrombotic occlusion of the lumen of the left anterior descending coronary artery with disruption of coronary arterial plaque which lead to ischemia of the anterior left ventricular myocardium. Analysis revealed the presence of adb-fubinaca in blood using LC–MS–MS methods for the detection which certified that this was indeed a fatal poisoning case due to overdose. Metabolites were also identified showing no significant contribution to acute kidney injury or thrombosis at this time. Adb-fubinaca may be metabolized by human liver microsomes in vitro models but further research is needed regarding metabolism and excretion as well as its potential link with aggression and violence seen in cases such as this one. Tandem mass spectrometry can also be used to detect adb-fubinaca from blood specimens collected from an inferior vena cava using 500 μL aliquots dissolved in acetonitrile for extraction at pH 10.2 into hexane–ethyl acetate followed by ultraperformance quadrupole−time‐of‐flight mass spectrometry ionization for confirmation purposes. Cayman Chemical Company provides reference standards for use with these methods so that new psychoactive substances such as adb-fubinaca can be detected accurately when encountered on an illicit drug market or online vendor site.
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ADB-FUBINACA has been used to detect new psychoactive substances and was first detected in 2014 by LC–MS–MS. In a case report of fatal poisoning, metabolites were identified in the blood specimen collected from the inferior vena cava. The specimen showed no significant levels of THC-COOH.
It is important to note that ADB-FUBINACA has been linked to aggression and violence in some users; a woman who had ingested the substance became violent and aggressive with her family before emergency personnel arrived a short time thereafter. Remarkable findings at autopsy included pulmonary vascular congestion and thrombotic occlusion of the lumen of the left anterior descending coronary artery due to disruption of coronary arterial plaque as well as ischemia of the anterior left ventricular myocardium.
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ADB-fubinaca is a synthetic cannabinoid receptor agonist, similar to amb-fubinaca and adb-fubinaca. It has become increasingly popular for the sale and use of synthetic substances. The drug was first detected in illegal products in 2014 when the cannabinoids were detected with a thiophene ring. The Drug Enforcement Administration found that these chemicals are the main psychoactive components of cannabimimetic quinolinyl carboxylates. As a derivative of α-PVT and an opioid, ADB-FUBINACA also acts as an opioid receptor agonist, similar to AH-7921 which was identified in illegal products extracted at pH 10.2. These drugs have been known to cause dangerous side effects, including anxiety, paranoia, cognitive impairment, and psychosis when used without caution or prescribed by a medical professional.
The Influence of the Synthetic Cannabinoids AMB-FUBINACA, ADB-FUBINACA, AB-CHMINACA, and THJ-2201 on In Vitro Viability and Senescence of SH-SY5Y Cells and Primary Rat Hippocampal Neurons
The influence of the synthetic cannabinoids AMB-FUBINACA, ADB-FUBINACA, AB-CHMINACA, and THJ-2201 on in vitro viability and senescence of SH-SY5Y cells and primary rat hippocampal neurons have been extensively studied. ADB-PINACA, an indazole-3-carboxamide, is a potent synthetic cannabinoid receptor agonist that has gained popularity online and is often bought or sold on vendor sites. Amb-fubinaca and adb-fubinaca have been found to exhibit similar use of the synthetic cannabinoid receptor found in THC. Chemical structure analysis with reference standards such as a thiophene derivative α-PVT and an opioid receptor agonist AH–7921 identified in illegal products has enabled the detection of new psychoactive substances such as adb–fubinaca. Clinical toxicology tests using LC–MS/MS methods for the detection of adb–fubinaca in blood samples have revealed remarkable findings at autopsy including pulmonary vascular congestion, thrombotic occlusion of the lumen of the left anterior descending coronary artery, disruption of coronary arterial plaque, ischemia of the anterior left ventricular myocardium etc. Adb–fubinaca may be detected using human liver microsomes for metabolism; ultraperformance liquid chromatography with tandem mass spectrometry (UPLC–MS/MS) was used to detect it in a fatal poisoning case. Metabolites were identified in 500 μL aliquot extracted from inferior vena cava with sodium fluoride and potassium oxalate at pH 10.2 into hexane–ethyl acetate followed by reconstitution into ultraperformance liquid chromatography quadrupole time–of–flight mass spectrometry (UPLC–QToF). This study provides valuable insight into the potential danger posed by these newly synthesized cannabinoids, particularly when combined with aggression and violence exhibited by individuals under its influence.
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Welcome to the world of ADB-FUBINACA! This synthetic cannabinoid, also known as a cannabinoid receptor agonist, is a potent and powerful chemical compound that can be used in toxicology assays, pharmacology studies, and online sales. ADB-FUBINACA is an indazole-3-carboxamide derivative of AB-PINACA and it has similar effects to THC (tetrahydrocannabinol). It is one of the new synthetic cannabinoids that has been used to detect CB1 and CB2 receptors in vitro models. The drug enforcement administration has certified it as the coronary thrombosis reference standard.
In addition, LC–MS–MS methods have been developed for the detection of ADB-FUBINACA in blood specimens collected from the inferior vena cava with sodium fluoride and potassium oxalate. The sample was extracted at pH 10.2 into hexane–ethyl acetate and then reconstituted into a 500 μL aliquot for analysis by ultraperformance liquid chromatography coupled with time-of-flight mass spectrometry.
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ADB-FUBINACA is a synthetic cannabinoid, which acts as a cannabinoid receptor agonist. It has been identified as the main component of many synthetic cannabis products and has been studied for its pharmacological properties and toxicology assay. ADB-FUBINACA is a potent agonist of the CB1 receptor, with an affinity that is slightly higher than that of AB-PINACA but lower than that of AB-CHMINACA. As such, its effects are more intense than those produced by the natural cannabinoids found in cannabis plant materials. In terms of pharmacology, ADB-FUBINACA exhibits strong activity at both the CB1 and CB2 receptors, making it one of the most effective synthetic cannabinoids available for sale. However, due to its potential health risks, it is illegal to buy or possess ADB-FUBINACA in many countries around the world.
ADB-FUBINACA research chemical properties
ADB-FUBINACA is a new psychoactive substance that is a synthetic cannabinoid used for recreational purposes. It has a chemical structure consisting of an indazole carboxamide group linked to the terminal amine group of the pentyl chain. Clinical toxicology research on ADB-FUBINACA has identified its potential as an opioid receptor agonist and ah-7921 was identified in illegal products containing ADB-FUBINACA. The substance was first detected in human liver microsome tests using time of flight mass spectrometry and it was also found to have similar properties as adbica and other cannabinoids detected with a thiophene ring. Studies have suggested that the use of ADB-FUBINACA may be associated with aggression and violence, although further investigations are needed to confirm this.
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ADB-FUBINACA is a synthetic cannabinoid that is believed to be more potent than its predecessor, AB-FUBINACA. It was first identified in 2015, and is similar to THC, the active ingredient in marijuana. ADB-FUBINACA has been linked to numerous adverse health effects, including seizures and death. It is classified as a Schedule I controlled substance by the Drug Enforcement Administration (DEA). As such, it is illegal to possess or distribute this substance in most countries. ADB-FUBINACA acts on the same brain receptors as THC, but its effects are much more powerful, making it highly dangerous and potentially life-threatening. Additionally, it has been linked to significant psychological disturbances that can last for days or weeks after use. For these reasons, it is important for individuals to stay informed about the potential dangers of using ADB-FUBINACA and other synthetic cannabinoids.