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Chemistry

4-HO-DPT is a psilocybin derivative and a structural homolog of psilocin. Repke et al. were the first to report the synthesis

In October 2019, researchers solved the crystal structure  They describe the structure as “…a singly protonated DPT cation, one half of a fumarate dianion (completed by a crystallographic centre of symmetry) and two water molecules of crystallization in the asymmetric unit.”

The Pharmacology

Little is known about the pharmacology of 4-HO-DPT. Alexander and Ann Shulgin documented their synthesis of 4-HO-DPT (#20 in TiHKAL), and describe a 20 mg oral dose as, “Possible threshold, nothing more.” ⁴

The Applications and Potential of 4-HO-DPT

Prior to the current work to solve its crystal structure, virtually nothing was known about 4-HO-DPT. Characterizing this fundamental structure is essential for all downstream research, such as structure-activity relationships that define the biological and clinical properties of the molecule. Understanding these relationships is key to developing effective drugs.

4-hydroxy-N,N-dipropyltryptamine, is a lesser-known hallucinogenic medication. It is the 4-hydroxyl simple of DPT. 4-HO-DPT was first orchestrated by Alexander Shulgin. In his book TiHKAL (Tryptamines I Have Known and Loved), neither the base dose nor the term are known. Produces few with no impacts. Almost no information exists about the pharmacological properties, digestion, and poisonous quality of 4-HO-DPT.